Skeletal muscle aging and the mitochondrion
نویسندگان
چکیده
منابع مشابه
Denervation and the Aging of Skeletal Muscle
There are many striking similarities in the reactions of mammalian skeletal muscle to denervation and the normal aging process. In both cases, the tissue environment is far more complex than has commonly been assumed, with satellite cell activation and new muscle fiber formation occurring simultaneously with atrophy and degeneration. Some of the changes that take place during aging can be attri...
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Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional cap...
متن کاملSkeletal Muscle Mitochondria and Aging: A Review
Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines in skeletal muscle mitochondria are thought to play a primary role in this process. Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched. Animal and human studies typically show that skeletal muscle mitochondria are altered with agi...
متن کاملApoptosis and Skeletal Muscle in Aging
Apoptosis is highly considered as a possible mechanism in the aging process of skeletal muscle. Age-related apoptosis pathways in aging skeletal muscle are several, and apoptotic stimuli considered as initiators could be of various type, such as calcium, TNF-α and oxidative stress. In the last decade, scientific research has focused on some topics in order to establish an appropriate lifestyle ...
متن کاملSkeletal Muscle Mitochondrial Energetic Efficiency and Aging
Aging is associated with a progressive loss of maximal cell functionality, and mitochondria are considered a key factor in aging process, since they determine the ATP availability in the cells. Mitochondrial performance during aging in skeletal muscle is reported to be either decreased or unchanged. This heterogeneity of results could partly be due to the method used to assess mitochondrial per...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2013
ISSN: 1043-2760
DOI: 10.1016/j.tem.2012.12.003